GE HealthCare has entered an agreement to acquire AI-based brain imaging company icometrix to expand its magnetic resonance (MR) imaging capabilities for neurological disorders.
The imaging giant stated that the purchase will enable it to integrate icometrix鈥檚 icobrain platform into existing MRI workflows, thereby meeting the growing demand for MRI in personalised treatment planning for conditions such as Alzheimer鈥檚 disease.
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A standout provision of the Belgian company鈥檚 platform is icobrain aria, claimed to be the first US Food and Drug Administration (FDA)-cleared AI solution for detecting and quantifying amyloid-related imaging abnormalities (ARIA) 鈥� a side effect associated with amyloid-targeting pharmaceutical therapies used in Alzheimer鈥檚 disease treatment.
Icometrix鈥檚 icobrain aria can identify ARIA-E (oedema/effusion) and ARIA-H (microhaemorrhages or haemosiderin deposits) from MR scans. Performing longitudinal analysis of ARIA occurrence over time, the tool is designed to give radiologists the ability to monitor Alzheimer鈥檚 disease patients鈥� response to anti-amyloid therapies.
GE HealthCare stated that it intends to expand patient access to the solution on all vendor MRI systems through commercial distribution and clinical integration.
GE HealthCare MR president and CEO Kelly Londy commented: 鈥淎long with our commitment to pushing the barriers of neuroscience research with our innovative MRI technology, we鈥檙e dedicated to strengthening our neurology portfolio and our MR imaging capabilities to provide advanced solutions to clinicians providing more precise care for patients both now and in the future.鈥�
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By GlobalDataEisai and Biogen鈥檚 Leqembi (lecanemab) and Eli Lilly鈥檚 Kisunla (donanemab), which received FDA approval in January 2023 and July 2024, respectively, represent the most significant disease-modifying treatments available for Alzheimer鈥檚 disease. The forecast is to generate global sales of , as per GlobalData analysis.
However, the two drugs have struggled with reimbursement in several territories due to narrow benefit-to-risk ratios and the need for frequent brain imaging before and during treatment, the latter adding expense.
In Lilly鈥檚 clinical trials of Kisunla, ARIA-E and ARIA-H were among the most common serious side effects observed, with Alzheimer鈥檚 disease patients with the APOE 蔚4 homozygous genotype found to be at significantly higher risk for developing ARIA.
